5  Treatments of VEXAS

5.1 Anti-inflmmatory treatments

• Anti-IL6R mAB
• JAKi

These above treatments do not help

5.2 Azacitidine

• French data Jachiet et al. (2025)

• UBA1 mutation burden correlates with response

5.3 Allo-HSCT

n= 33 Gurnari et al. (2024)

Gurnari, Carmelo, Linda Koster, Laurien Baaij, et al. 2024. “Allogeneic Hematopoietic Cell Transplantation for VEXAS Syndrome: Results of a Multicenter Study of the EBMT.” Blood Advances 8 (6): 1444–48. https://doi.org/10.1182/bloodadvances.2023012478.

Jachiet, Vincent, Olivier Kosmider, Maxime Beydon, et al. 2025. “Efficacy and Safety of Azacitidine for VEXAS Syndrome: A Large-Scale Retrospective Study from the FRENVEX Group.” Blood Journal, ahead of print, May 15. https://doi.org/10.1182/blood.2024028133.